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Drug-associated neurotoxicity occurs less often than with other commonly used vinca alkaloid compounds.
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A favorite combination is dracaenas, Nutt or Beauté Poitevine, with the variegated vinca as a front border.
3
It may be induced by prolonged exposure of cells to drugs such as doxorubicin, etoposide and vinca alkaloids.
4
There is a promising activity of new drug combinations, such as vinca alkaloids and taxanes in association with estramustine.
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This strategy has allowed fast access to a family of vinca alkaloid derivatives with an enlarged and functionalized ring C'.
6
We conclude that resistance to anthracyclines and vinca alkaloids in childhood relapsed ALL is not due to P-glycoprotein mediated MDR.
7
A related species (the Madagascar periwinkle) was the original source of a number of vinca alkaloids which remain important in treating cancer.
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Background: Vinflunine is a novel vinca alkaloid obtained by semi-synthesis using super-acidic chemistry to selectively introduce two fluorine atoms at the 20' position of vinorelbine.
9
Drugs that affect microtubule dynamics, including the taxanes and vinca alkaloids, have been a mainstay in the treatment of leukemias and solid tumors for decades.
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The overall response rate of 37% was independent of prior exposure to intermittent intravenous vinca alkaloids or prior response to front-line doxorubicin combination chemotherapy.
11
Asters, alyssum, balsams, candytuft, celosia, coleus, dianthus (pink), lobelia, mignonette, petunias, phlox, portulaca, ricinus, salvia, verbenas, vinca, roses, zinnias, may all be started from seed.
12
CI-980, a 1-deaza-7,8-dihydropteridine, is a novel anticancer agent that is a potent mitotic inhibitor acting as a tubulin binder similar to the vinca alkaloids.
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A number of studies show that some Vinca alkaloids inhibit CaM-target interaction.
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Vinca alkaloids have been used as chemotherapeutic agents now for over three decades.
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Vinca alkaloids and platinum compounds were the main neurotoxic agents.
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Both agents selected for cross resistance to the Vinca alkaloids.